Endocrine Abstracts

Objective: Evaluate the influence of altered cortisol binding globulin (CBG) concentration on total cortisol and calculated free cortisol (CFC) during the 250 μg ACTH test.Methods: We included 100 unmedicated healthy individuals (HI) (50M:50F), 13 women taking oral contraception (OC), and 5 men with nefrotic syndrome (NS, prior to glucocorticoid treatment; hypoalbuminaemia <9 g/l; proteinuria >1.6 g/24 h). An ACTH-test was performed between ...

Patients with growth hormone deficiency (GHD) have increased risk of bone fractures. Despite a well-known decrease in bone mineral density (BMD) and content (BMC) in these patients, these changes in bone mineralization cannot explain the increase in fracture rate alone. The purpose of this study was to evaluate collagen morphology in cortical bone from GHD rats in order to provide a further explanation for the increased fracture rate seen in GHD patients.<p class="abstext...